Endemic threshold results in an age-duration-structured population model for HIV infection.
نویسنده
چکیده
In this paper we consider an age-duration-structured population model for HIV infection in a homosexual community. First we investigate the invasion problem to establish the basic reproduction ratio R(0) for the HIV/AIDS epidemic by which we can state the threshold criteria: The disease can invade into the completely susceptible population if R(0)>1, whereas it cannot if R(0)<1. Subsequently, we examine existence and uniqueness of endemic steady states. We will show sufficient conditions for a backward or a forward bifurcation to occur when the basic reproduction ratio crosses unity. That is, in contrast with classical epidemic models, for our HIV model there could exist multiple endemic steady states even if R(0) is less than one. Finally, we show sufficient conditions for the local stability of the endemic steady states.
منابع مشابه
ON THE STABILITY AND THRESHOLD ANALYSIS OF AN EPIDEMIC MODEL
We consider a mathematical model of epidemic spread in which the population is partitioned into five compartments of susceptible S(t), Infected I(t), Removed R(t), Prevented U(t) and the Controlled W(t). We assume each of the compartments comprises of cohorts of individuals which are identical with respect to the disease status. We derive five systems of equations to represent each of the ...
متن کاملStability Analysis of a Fractional Order Model of HIV virus and AIDS Infection in the Community
In this paper a non-linear model with fractional order is presented for analyzing and controlling the spread of HIV virus. Both the disease-free equilibrium and the endemic equilibrium are found and their stability is discussed. The basic reproduction number , which is a function of the constant parameters in the model, plays an essential role in the stability of the ...
متن کاملExistence, multiplicity and stability of endemic states for an age-structured S-I epidemic model.
We study an S-I type epidemic model in an age-structured population, with mortality due to the disease. A threshold quantity is found that controls the stability of the disease-free equilibrium and guarantees the existence of an endemic equilibrium. We obtain conditions on the age-dependence of the susceptibility to infection that imply the uniqueness of the endemic equilibrium. An example with...
متن کاملAn epidemic model for the transmission dynamics of HIV/AIDS with different clinical stages
In this paper, a five–dimensional mathematical model is proposed for the transmission dynamics of HIV/AIDS within a population of varying size. In writing the model, we have divided the population under consideration into five sub classes of susceptible, infective, pre-AIDS, AIDS related complex and that of AIDS patients. The model has two non- negative equilibria namely, a disease free and the...
متن کاملAn age-structured model for the coupled dynamics of HIV and HSV-2.
Evidence suggests a strong correlation between the prevalence of HSV-2 (genital herpes) and the perseverance of the HIV epidemic. HSV-2 is an incurable viral infection, characterized by periodic reactivation. We construct a model of the co-infection dynamics between the two diseases by incorporating a time-since-infection variable to track the alternating periods of infectiousness of HSV-2. The...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Mathematical biosciences
دوره 201 1-2 شماره
صفحات -
تاریخ انتشار 2006